Article
[Analysis of linkage and association of alleles of proinflammatory cytokines genes IL-6, IFNg and TNF with multiple sclerosis using transmission disequilibrium test (TDT)].
Molekuliarnaia biologiia - 1 Jan 2000
Makarycheva O Iu, Tsareva E Iu, Sudomoina M A, Kulakova O G, Bykova O V, Gol'tsova N V, Kuzenkova L M, Boĭko A N, Favorova O O
Abstract excerpt
Proinflammatory cytokines Interleukin-6 (IL-6), Interferon-gamma (IFNg) and Tumor necrosis factor (TNF) are known as participants of inflammation and play an important role in pathogenesis of multiple sclerosis (MS). Based on literature data about influence of SNPs G(-308)A of TNF gene, A(+874)T of IFNG gene and G(-174)C of IL-6 gene on production of these cytokines, we investigated association of these...
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