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Article

Swainsonine, an inhibitor of glycoprotein processing, enhances cytotoxicity of large granular lymphocytes.

Scandinavian journal of immunology - 1 Mar 1990

Yagita M, Saksela E

Abstract excerpt

In the present study we investigated the effects of inhibitors of glycoprotein processing on cytotoxicity of human large granular lymphocytes (LGL). The incubation of LGL for 36 h with 0.5 microgram/ml swainsonine (SW), which is an inhibitor of mannosidase II, resulted in the augmentation of cytotoxicity of LGL against an NK-resistant colon carcinoma cell line (Colo-320DM) without increase of binding frequency of...

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Identifiers

PMID: 2108487
DOI: 10.1111/j.1365-3083.1990.tb02769.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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