Swainsonine, an inhibitor of glycoprotein processing, enhances cytotoxicity of large granular lymphocytes.

doi:10.1111/j.1365-3083.1990.tb02769.x

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Article

Swainsonine, an inhibitor of glycoprotein processing, enhances cytotoxicity of large granular lymphocytes.

Scandinavian journal of immunology - 1 Mar 1990

Yagita M, Saksela E

Abstract excerpt

In the present study we investigated the effects of inhibitors of glycoprotein processing on cytotoxicity of human large granular lymphocytes (LGL). The incubation of LGL for 36 h with 0.5 microgram/ml swainsonine (SW), which is an inhibitor of mannosidase II, resulted in the augmentation of cyto...

Topics

Alkaloids
Binding Sites
Cells, Cultured
Concanavalin A
Cytotoxicity, Immunologic
Glycoproteins
Humans
Interleukin-2
Lymphocyte Activation
Lymphocytes
Mannosidases
Phenotype
Receptors, Interleukin-2
Swainsonine

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