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Article

The evolution of virulence in RNA viruses under a competition-colonization trade-off.

Bulletin of mathematical biology - 1 Aug 2011

Delgado-Eckert Edgar, Ojosnegros Samuel, Beerenwinkel Niko

Abstract excerpt

RNA viruses exist in large intra-host populations which display great genotypic and phenotypic diversity. We analyze a model of viral competition between two viruses infecting a constantly replenished cell pool. We assume a trade-off between the ability of the virus to colonize new cells (cell killing rate or virulence) and its local competitiveness (replicative success within coinfected cells). We characterize...

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PMID: 21082274
DOI: 10.1007/s11538-010-9596-2

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