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Article

The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications

4 Nov 2010

Abstract excerpt

We report a computational approach that integrates structural bioinformatics, molecular modelling and systems biology to construct a drug-target network on a structural proteome-wide scale. The approach has been applied to the genome of Mycobacterium tuberculosis (M.tb), the causative agent of one of today's most widely spread infectious diseases. The resulting drug-target interaction network for all structurally...

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PMID: 21079673
DOI: 10.1371/journal.pcbi.1000976

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