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Article

Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells.

BMC systems biology - 4 Nov 2010

Linde Jörg, Wilson Duncan, Hube Bernhard, Guthke Reinhard

Abstract excerpt

BACKGROUND: Reverse engineering of gene regulatory networks can be used to predict regulatory interactions of an organism faced with environmental changes, but can prove problematic, especially when focusing on complicated multi-factorial processes. Candida albicans is a major human fungal pathogen. During the infection process, this fungus is able to adapt to conditions of very low iron availability. Such...

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Identifiers

PMID: 21050438
DOI: 10.1186/1752-0509-4-148
PMCID: PMC3225834

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