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Article

Dominant Cx26 mutants associated with hearing loss have dominant-negative effects on wild type Cx26.

Molecular and cellular neurosciences - 1 Jun 2011

Zhang Junxian, Scherer Steven S, Yum Sabrina W

Abstract excerpt

Mutations in GJB2, the gene encoding the human gap junction protein connexin26 (Cx26), cause either non-syndromic hearing loss or syndromes affecting both hearing and skin. We have investigated whether dominant Cx26 mutants can interact physically with wild type Cx26. HeLa cells stably expressing wild type Cx26 were transiently transfected to co-express nine individual dominant Cx26 mutants; six associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21040787
DOI: 10.1016/j.mcn.2010.10.002
PMCID: PMC3132585

Genes

GJB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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