Article
Relationship between deoxycytidine kinase (DCK) genotypic variants and fludarabine toxicity in patients with follicular lymphoma.
Leukemia research - 1 Apr 2011
Rivero Ana, Rapado Inmaculada, Tomás José F, Montalbán Carlos, de Oña Raquel, Paz-Carreira José, Canales Miguel, Martínez Rafael, Sánchez-Godoy Pedro, de Sevilla Alberto Fernández, de la Serna Javier, Martínez-López Joaquín
Abstract excerpt
DCK catalyzes the intracellular phosphorylation of fludarabine. The promoter and coding region of the DCK gene were analyzed in 74 follicular lymphoma (FL) patients receiving a therapeutic regimen that included fludarabine. DCK mRNA expression was quantified in a cohort of healthy donors. Four previously described genotypic variants, -360C>G, -201C>T (rs2306744), C28624T (rs11544786) and c.91+37G>C (rs9997790),...
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