Article
Localized hypermutation and associated gene losses in legume chloroplast genomes.
Genome research - 1 Dec 2010
Magee Alan M, Aspinall Sue, Rice Danny W, Cusack Brian P, Sémon Marie, Perry Antoinette S, Stefanović Sasa, Milbourne Dan, Barth Susanne, Palmer Jeffrey D, Gray John C, Kavanagh Tony A, Wolfe Kenneth H
Abstract excerpt
Point mutations result from errors made during DNA replication or repair, so they are usually expected to be homogeneous across all regions of a genome. However, we have found a region of chloroplast DNA in plants related to sweetpea (Lathyrus) whose local point mutation rate is at least 20 times higher than elsewhere in the same molecule. There are very few precedents for such heterogeneity in any genome, and we...
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