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Article

The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6)

1 Oct 2010

Abstract excerpt

Mutations in THAP1 have been associated with dystonia 6. THAP1 encodes a transcription factor with mostly unknown targets. We tested the hypothesis that THAP1 regulates the expression of DYT1 (TOR1A), another dystonia-causing gene. After characterization of the TOR1A promoter, we demonstrate that THAP1 binds to the core promoter of TOR1A. Further, we report that wild type THAP1 represses the expression of TOR1A,...

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PMID: 20976771
DOI: 10.1002/ana.22157

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The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6)PMID 20976771Read ↗

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