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Article

Direct interaction between causative genes of DYT1 and DYT6 primary dystonia.

Annals of neurology - 1 Oct 2010

Gavarini Sophie, Cayrol Corinne, Fuchs Tania, Lyons Natalia, Ehrlich Michelle E, Girard Jean-Philippe, Ozelius Laurie J

Abstract excerpt

Primary dystonia is a movement disorder characterized by sustained muscle contractions and in which dystonia is the only or predominant clinical feature. TOR1A(DYT1) and the transcription factor THAP1(DYT6) are the only genes identified thus far for primary dystonia. Using electromobility shift assays and chromatin immunoprecipitation (ChIP) quantitative polymerase chain reaction (qPCR), we demonstrate a physical...

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Identifiers

PMID: 20865765
DOI: 10.1002/ana.22138
PMCID: PMC3038652

Genes

THAP1

Provenance

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Direct interaction between causative genes of DYT1 and DYT6 primary dystonia.PMID 20865765Read ↗

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