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Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification

31 Mar 2010

Abstract excerpt

Leprosy is an infectious disease caused by Mycobacterium leprae. M. leprae has undergone a major reductive evolution leaving a minimal set of functional genes for survival. It remains non-cultivable. As M. leprae develops resistance against most of the drugs, novel drug targets are required in order to design new drugs. As most of the essential genes mediate several biosynthetic and metabolic pathways, the...

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PMID: 20975887
DOI: 10.6026/97320630004392

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