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Article

CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Wickliffe Jeffrey K, Abdel-Rahman Sherif Z, Lee Chul, Kormos-Hallberg Csilla, Sood Gagan, Rondelli Catherine M, Grady James J, Desnick Robert J, Anderson Karl E

Abstract excerpt

Porphyria cutanea tarda (PCT) is a cutaneous porphyria with sporadic (type 1) and familial (type 2) subtypes, both resulting from decreased hepatic uroporphyrinogen decarboxylase (UROD) activity. Environmental and genetic factors are involved in the development of PCT, and genetic variants in the cytochrome P450 (CYP ) genes, CYP1A1 and CYP1A2, have been implicated. We investigated the association between PCT and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20957336
DOI: 10.2119/molmed.2010.00130
PMCID: PMC3060985

Genes

GSTM1
UROD
GSTT1
HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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