Article
Molecular and clinical analysis of Japanese patients with persistent congenital hyperinsulinism: predominance of paternally inherited monoallelic mutations in the KATP channel genes.
The Journal of clinical endocrinology and metabolism - 1 Jan 2011
Yorifuji Tohru, Kawakita Rie, Nagai Shizuyo, Sugimine Akinori, Doi Hiraku, Nomura Anryu, Masue Michiya, Nishibori Hironori, Yoshizawa Akihiko, Okamoto Shinya, Doi Ryuichiro, Uemoto Shinji, Nagasaka Hironori
Abstract excerpt
BACKGROUND: Preoperative identification of the focal form of congenital hyperinsulinism is important for avoiding unnecessary subtotal pancreatectomy. However, neither the incidence nor the histological spectrum of the disease is known for Japanese patients. AIMS: The aim of the study was to elucidate the molecular and histological spectrum of congenital hyperinsulinism in Japan. SUBJECTS: Thirty-six Japanese...
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