Article
A DNA Methylation Study of the Amyloid Precursor Protein Gene in Several Brain Regions from Patients with Familial Alzheimer Disease
4 Oct 2010
Abstract excerpt
Presence of extracellular amyloid plaques is a neuropathological hallmark of Alzheimer disease. Here the authors have compared the methylation status of a CpG-island in the amyloid precursor protein gene (APP) in DNA extracted from the more plaque-vulnerable cortex regions with DNA from the more plaque-resistant cerebellum using material from six familial Alzheimer disease cases. Bisulfite sequencing of a 188 bp...
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