Article
The left and right ventricle of a patient with a R723G mutation of the beta-myosin heavy chain and severe hypertrophic cardiomyopathy show no differences in the expression of myosin mRNA.
Cardiology journal - 1 Jan 2010
Borchert Bianca, Tripathi Snigdha, Francino Antonio, Navarro-Lopez Francisco, Kraft Theresia
Abstract excerpt
BACKGROUND: In familial hypertrophic cardiomyopathy (FHC), asymmetric left ventricular (LV) hypertrophy has been considered to be the predominant phenotypic expression, whereas right ventricular (RV) involvement is still ambiguous. In most cases, the right ventricle remains unaffected until secondary pulmonary hypertension develops. Several FHC-causing mutations of genes encoding sarcomere-related proteins have...
Topics
- Cardiac Myosins
- Cardiomyopathy, Hypertrophic, Familial
- Heart Transplantation
- Heart Ventricles
- Humans
- Male
- Middle Aged
- Myosin Heavy Chains
- Phenotype
- Point Mutation
- RNA, Messenger
- Severity of Illness Index
- Ultrasonography