Article
Shared desmosome gene findings in early and late onset arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Journal of cardiovascular translational research - 1 Dec 2010
Tan Boon Yew, Jain Rahul, den Haan A Dénise, Chen Yan, Dalal Darshan, Tandri Harikrishna, Amat-Alarcon Nuria, Daly Amy, Tichnell Crystal, James Cynthia, Calkins Hugh, Judge Daniel P
Abstract excerpt
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited form of cardiomyopathy with low penetrance and variable expressivity. Dominant mutations and rare polymorphisms in desmosome genes are frequently identified. We reasoned that individuals with earlier onset disease would have more frequent desmosome gene mutations and rare polymorphisms. Three groups were compared: Young with...
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