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Profiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas

24 Aug 2010

Abstract excerpt

BACKGROUND: Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the predicted target genes in ULMs and matched myometria. METHODOLOGY/PRINCIPAL FINDINGS: Patterns of inverse...

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PMID: 20808773
DOI: 10.1371/journal.pone.0012362

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