Article
Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis.
Lancet (London, England) - 4 Sept 2010
Gale Daniel P, de Jorge Elena Goicoechea, Cook H Terence, Martinez-Barricarte Rubén, Hadjisavvas Andreas, McLean Adam G, Pusey Charles D, Pierides Alkis, Kyriacou Kyriacos, Athanasiou Yiannis, Voskarides Konstantinos, Deltas Constantinos, Palmer Andrew, Frémeaux-Bacchi Véronique, de Cordoba Santiago Rodriguez, Maxwell Patrick H, Pickering Matthew C
Abstract excerpt
BACKGROUND: Complement is a key component of the innate immune system, and variation in genes that regulate its activation is associated with renal and other disease. We aimed to establish the genetic basis for a familial disorder of complement regulation associated with persistent microscopic ha...
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