Article
Polytomous logistic regression as a tool for exploring heterogeneity across birth defect subtypes: an example using anencephaly and spina bifida.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2010
Lupo Philip J, Symanski Elaine, Waller D Kim, Chan Wenyaw, Canfield Mark A, Langlois Peter H, Mitchell Laura E
Abstract excerpt
BACKGROUND: In birth defect epidemiology, phenotypic subgroups are often combined into a composite phenotype in an effort to increase statistical power. Although the validity of using composite phenotypes has been questioned, formal evaluations of the underlying assumption of effect homogeneity across component phenotypes have not been conducted. METHODS: Polytomous logistic regression was used to assess effect...
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