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Article

Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells.

Journal of hepato-biliary-pancreatic sciences - 1 Nov 2010

Yamada Norishige, Nishida Yukari, Yokoyama Seiya, Tsutsumida Hideaki, Houjou Izumi, Kitamoto Sho, Goto Masamichi, Higashi Michiyo, Yonezawa Suguru

Abstract excerpt

BACKGROUND AND PURPOSE: High de novo expression of MUC5AC (a gastric-type secreted mucin) is observed in many types of pancreatobiliary neoplasms, including precursor lesions. In this study, we show that the DNA methylation pattern is intimately correlated with MUC5AC expression in ten cancer cel...

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Share to Biliary Tract Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 20734208
DOI: 10.1007/s00534-010-0278-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20734208-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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