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Induction of cellular apoptosis in human breast cancer by DLBS1425, aPhaleria macrocarpacompound extract, via down-regulation of PI3-kinase/AKT pathway

15 Oct 2010

Abstract excerpt

Phaleria macrocarpa, also known as Mahkota dewa, is an Indonesian native plant that has been used as a remedy for many diseases. However, the molecular mechanism of Phaleria macrocarpa is still limited. In this study, we evaluate its molecular mechanism using a bioactivity-guided DLBS1425, an extract of Phaleria macrocarpa on MDA-MB-231 breast cancer cell line. DLBS1425 exhibited inhibition of proliferative,...

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PMID: 20703095
DOI: 10.4161/cbt.10.8.13085

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