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Article

Trivalent arsenic inhibits the functions of chaperonin complex.

Genetics - 1 Oct 2010

Pan Xuewen, Reissman Stefanie, Douglas Nick R, Huang Zhiwei, Yuan Daniel S, Wang Xiaoling, McCaffery J Michael, Frydman Judith, Boeke Jef D

Abstract excerpt

The exact molecular mechanisms by which the environmental pollutant arsenic works in biological systems are not completely understood. Using an unbiased chemogenomics approach in Saccharomyces cerevisiae, we found that mutants of the chaperonin complex TRiC and the functionally related prefoldin complex are all hypersensitive to arsenic compared to a wild-type strain. In contrast, mutants with impaired ribosome...

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Identifiers

PMID: 20660648
DOI: 10.1534/genetics.110.117655
PMCID: PMC2954479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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