Inhibition of superinfection and the evolution of viral latency.

doi:10.1128/JVI.00865-10

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Article

Inhibition of superinfection and the evolution of viral latency.

Journal of virology - 1 Oct 2010

Berngruber Thomas W, Weissing Franz J, Gandon Sylvain

Abstract excerpt

Latent viruses generally defend their host cell against superinfection by nonlatent virulent mutants that could destroy the host cell. Superinfection inhibition thus seems to be a prerequisite for the maintenance of viral latency. Yet viral latency can break down when resistance to superinfection inhibition, known as ultravirulence, occurs. To understand the evolution of viral latency, we have developed a model...

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