Article
Bortezomib therapeutic effect is associated with expression and mutation of FGFR3 in human lymphoma cells.
Anticancer research - 1 Jun 2010
Zheng Weiyan, Guan Min, Zhu Lijun, Cai Zhen, Chung Vincent, Huang He, Yen Yun
Abstract excerpt
OBJECTIVE: Ectopically expressed and deregulated fibroblast growth factor receptor 3 (FGFR3) has been observed in many malignant cancer patients, including those with lymphoma. This study investigated whether the therapeutic effect of bortezomib in lymphoma is associated with FGFR3-expression. MATERIALS AND METHODS: Cell proliferation and apoptosis assays were performed in minimal FGFR3 expressing U937 cells and...
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