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Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes

23 Jul 2010

Abstract excerpt

RATIONALE: MicroRNAs (miRNAs) have been implicated in the epigenetic regulation of key metabolic, inflammatory, and antiangiogenic pathways in type 2 diabetes (DM) and may contribute to common disease complications. OBJECTIVE: In this study, we explore plasma miRNA profiles in patients with DM. METHODS AND RESULTS: Total RNA was extracted from plasma samples of the prospective population-based Bruneck study. A...

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PMID: 20651284
DOI: 10.1161/circresaha.110.226357

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