Article
Metabolomic profiles indicate distinct physiological pathways affected by two loci with major divergent effect on Bos taurus growth and lipid deposition.
Physiological genomics - 1 Oct 2010
Weikard Rosemarie, Altmaier Elisabeth, Suhre Karsten, Weinberger Klaus M, Hammon Harald M, Albrecht Elke, Setoguchi Kouji, Takasuga Akiko, Kühn Christa
Abstract excerpt
Identifying trait-associated genetic variation offers new prospects to reveal novel physiological pathways modulating complex traits. Taking advantage of a unique animal model, we identified the I442M mutation in the non-SMC condensin I complex, subunit G (NCAPG) gene and the Q204X mutation in the growth differentiation factor 8 (GDF8) gene as substantial modulators of pre- and/or postnatal growth in cattle. In a...
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