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Article

High-throughput in vivo vertebrate screening.

Nature methods - 1 Aug 2010

Pardo-Martin Carlos, Chang Tsung-Yao, Koo Bryan Kyo, Gilleland Cody L, Wasserman Steven C, Yanik Mehmet Fatih

Abstract excerpt

We demonstrate a high-throughput platform for cellular-resolution in vivo chemical and genetic screens on zebrafish larvae. The system automatically loads zebrafish from reservoirs or multiwell plates, and positions and rotates them for high-speed confocal imaging and laser manipulation of both superficial and deep organs within 19 s without damage. We performed small-scale test screening of retinal axon guidance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20639868
DOI: 10.1038/nmeth.1481
PMCID: PMC2941625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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