Chromosomal abnormalities in transformed Ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations.

doi:10.1002/gcc.20802

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Article

Chromosomal abnormalities in transformed Ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations.

Genes, chromosomes & cancer - 1 Oct 2010

Nguyen-Khac Florence, Lesty Claude, Eclache Virginie, Couronné Lucile, Kosmider Olivier, Andrieux Joris, Collonge-Rame Marie-Agnes, Penther Dominique, Lafage Marina, Bilhou-Nabera Chrystele, Chapiro Elise, Mozziconacci Marie-Joelle, Mugneret Francine, Gachard Nathalie, Nadal Nathalie, Lippert Eric, Struski Stephanie, Dastugue Nicole, Cabrol Christine, Bernard Olivier A

Abstract excerpt

Evolution to myelofibrosis (MF), acute myeloid leukemia or myelodysplastic syndrome (AML/MDS) may occur over time in myeloproliferative neoplasms (MPN) patients most likely due to the acquisition of additional mutations. The Groupe Francophone de cytogenetique hematologique (GFCH) has collected and reviewed 82 patients with transformation of MPN (66 AML/MDS and 16 MF). JAK2V617F and TET2 mutations were searched...

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PMID: 20629097
DOI: 10.1002/gcc.20802

Genes

TET2
JAK2

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