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Article

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

1 Jan 2010

Abstract excerpt

BACKGROUND: Hypoxia is a condition of low oxygen tension occurring in the tumor microenvironment and it is related to poor prognosis in human cancer. To examine the relationship between hypoxia and neuroblastoma, we generated and tested an in vitro derived hypoxia gene signature for its ability to predict patients' outcome. RESULTS: We obtained the gene expression profile of 11 hypoxic neuroblastoma cell lines...

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Share to Cancer, Hypoxia, and Metabolism
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PMID: 20624283
DOI: 10.1186/1476-4598-9-185

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