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Article

Microfluidic approach to create three-dimensional tissue models for biofilm-related infection of orthopaedic implants.

Tissue engineering. Part C, Methods - 1 Jan 2011

Lee Joung-Hyun, Wang Hongjun, Kaplan Jeffrey B, Lee Woo Y

Abstract excerpt

With conventional in vitro culture methods, it is difficult to study complex interactions of host cells with pathogens and drugs in physiologically relevant microenvironments. To simulate orthopaedic implant-associated infection, a multi-channel microfluidic device was used to (1) observe in real-time the development of osteoblasts into three-dimensional (3D) tissue-like structures and (2) study how this...

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Identifiers

PMID: 20618080
DOI: 10.1089/ten.TEC.2010.0285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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