Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular evolution of the fibulins: implications on the functionality of the elastic fibulins.

Gene - 15 Sept 2010

Segade Fernando

Abstract excerpt

The fibulins form a family of secreted proteins associated with the basement membrane, cell adhesive structures, and elastic fibers characterized by the presence of a unique fibulin-like C-terminal domain preceded by a rod-like tandem array of calcium-binding EGF modules. We traced the origin of the fibulin gene family to the base of the metazoans. In invertebrates, Fibulin-1 and Hemicentin comprise the fibulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Elastic Tissue
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix

Share to Gene Duplication

Share to Gene Expression

Share to Invertebrates

Share to Vertebrates

Source

Identifiers

PMID: 20595023
DOI: 10.1016/j.gene.2010.05.003

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular evolution of the fibulins: implications on the functionality of the elastic fibulins.PMID 20595023Read ↗

Fibulins: multiple roles in matrix structures and tissue functions.Semantic proximity Read ↗

Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivoSemantic proximity Read ↗

Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner.Semantic proximity Read ↗

Extracellular Interactions between Fibulins and Transforming Growth Factor (TGF)-β in Physiological and Pathological ConditionsSemantic proximity Read ↗

The role of adhesion protein Fibulin7 in development and diseasesSemantic proximity Read ↗

Roles of Fibulin-2 in CarcinogenesisSemantic proximity Read ↗

Fibulin-5, an integrin-binding matricellular protein: its function in development and diseaseSemantic proximity Read ↗

Hemicentins: what have we learned from worms?Semantic proximity Read ↗

Fibulins: physiological and disease perspectivesSemantic proximity Read ↗

The kindlin family: functions, signaling properties and implications for human diseaseSemantic proximity Read ↗

Comparative Studies of Vertebrate Beta Integrin Genes and Proteins: Ancient Genes in Vertebrate EvolutionSemantic proximity Read ↗

Fibulin-2 is dispensable for mouse development and elastic fiber formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.