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Article

Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma.

Cancer research - 15 Jul 2010

Christensen Brock C, Houseman E Andres, Poage Graham M, Godleski John J, Bueno Raphael, Sugarbaker David J, Wiencke John K, Nelson Heather H, Marsit Carmen J, Kelsey Karl T

Abstract excerpt

Development of mesothelioma is linked mainly to asbestos exposure, but the combined contributions of genetic and epigenetic alterations are unclear. We investigated the potential relationships between gene copy number (CN) alterations and DNA methylation profiles in a case series of pleural mesotheliomas (n = 23). There were no instances of significantly correlated CN alteration and methylation at probed loci,...

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Share to DNA (Cytosine-5-)-Methyltransferase 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20587528
DOI: 10.1158/0008-5472.CAN-10-0190
PMCID: PMC2905466

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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