Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency.

doi:10.1203/PDR.0b013e3181ed8609

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Article

Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency.

Pediatric research - 1 Oct 2010

Waleh Nahid, Hodnick Ryan, Jhaveri Nami, McConaghy Suzanne, Dagle John, Seidner Steven, McCurnin Donald, Murray Jeffrey C, Ohls Robin, Clyman Ronald I

Abstract excerpt

Three independent risk factors (immature gestation, absence of antenatal glucocorticoid exposure, and presence of the rs2817399(A) allele of the gene TFAP2B) are associated with patent ductus arteriosus (PDAs) that fail to close during prostaglandin inhibition. We hypothesized that these three factors may affect a common set of genes that increase the risk of persistent PDA after birth. We studied baboon ductus...

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PMID: 20581741
DOI: 10.1203/PDR.0b013e3181ed8609
PMCID: PMC2940964

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KCNA2

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