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New World Hantaviruses Activate IFNλ Production in Type I IFN-Deficient Vero E6 Cells

17 Jun 2010

Abstract excerpt

BACKGROUND: Hantaviruses indigenous to the New World are the etiologic agents of hantavirus cardiopulmonary syndrome (HCPS). These viruses induce a strong interferon-stimulated gene (ISG) response in human endothelial cells. African green monkey-derived Vero E6 cells are used to propagate hantaviruses as well as many other viruses. The utility of the Vero E6 cell line for virus production is thought to owe to...

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PMID: 20567522
DOI: 10.1371/journal.pone.0011159

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