Article
Identification of a Kir3.4 mutation in congenital long QT syndrome.
American journal of human genetics - 11 Jun 2010
Yang Yanzong, Yang Yiqing, Liang Bo, Liu Jinqiu, Li Jun, Grunnet Morten, Olesen Søren-Peter, Rasmussen Hanne B, Ellinor Patrick T, Gao Lianjun, Lin Xiaoping, Li Li, Wang Lei, Xiao Junjie, Liu Yi, Liu Ying, Zhang Shulong, Liang Dandan, Peng Luying, Jespersen Thomas, Chen Yi-Han
Abstract excerpt
Congenital long QT syndrome (LQTS) is a hereditary disorder that leads to sudden cardiac death secondary to fatal cardiac arrhythmias. Although many genes for LQTS have been described, the etiology remains unknown in 30%-40% of cases. In the present study, a large Chinese family (four generations, 49 individuals) with autosomal-dominant LQTS was clinically evaluated. Genome-wide linkage analysis was performed by...
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