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Article

Hereditary Colon Cancer: Lynch Syndrome

17 Jun 2010

Abstract excerpt

Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or...

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PMID: 20559516
DOI: 10.5009/gnl.2010.4.2.151

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