Article
P-cadherin, vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study.
Histology and histopathology - 1 Aug 2010
Sousa Bárbara, Paredes Joana, Milanezi Fernanda, Lopes Nair, Martins Diana, Dufloth Rozany, Vieira Daniella, Albergaria André, Veronese Luiz, Carneiro Vitor, Carvalho Sílvia, Costa José Luis, Zeferino Luiz, Schmitt Fernando
Abstract excerpt
INTRODUCTION: The most suitable immunohistochemical criterion to identify basal-like breast carcinomas (BLBC), a molecular subgroup of breast cancer associated with poor prognosis, is the triple negative phenotype along with CK5 and/or EGFR immunoreactivity. However, several putative basal markers have been suggested as alternatives to identify BLBC with more accuracy. EXPERIMENTAL DESIGN: The expression of CK5,...
Topics
- Breast Neoplasms
- Cadherins
- Carcinoma
- Female
- Humans
- Immunohistochemistry
- Phenotype
- Receptor, ErbB-2
- Vimentin