Article
1H NMR study of the influence of mutation on the interaction of the C-terminus with the active site in heme oxygenase from Neisseria meningitidis: implications for product release.
Biochemistry - 20 Jul 2010
Peng Dungeng, Ma Li-Hua, Ogura Hiroshi, Yang En-Che, Zhang Xuhong, Yoshida Tadashi, La Mar Gerd N
Abstract excerpt
The HO from the pathogenic bacterium Neisseria meningitidis, NmHO, possesses C-terminal His207, Arg208, and His209 residues that are undetected in crystal structures. NMR found the C-terminus ordered and interacting with the active site and shown to undergo a spontaneous cleavage of the C-termina...
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