Article
Dental agenesis in Kallmann syndrome individuals with FGFR1 mutations.
International journal of paediatric dentistry - 1 Jul 2010
Bailleul-Forestier Isabelle, Gros Catherine, Zenaty Delphine, Bennaceur Sélim, Leger Juliane, de Roux Nicolas
Abstract excerpt
BACKGROUND: Kallmann syndrome (KS) is a rare genetic disorder characterised by central hypogonadism with a lack of sense of smell and in some cases renal aplasia, deafness, syndactyly, cleft lip/palate, and dental agenesis. To date, five genes for KS have been identified: KAL1, located on the X chromosome, and FGFR1, PROKR2, PROK2 and FGF8, which are involved in autosomally transmitted forms of KS. AIM: The study...
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