Article
The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche.
Blood - 16 Sept 2010
Visigalli Ilaria, Ungari Silvia, Martino Sabata, Park Hyejung, Cesani Martina, Gentner Bernhard, Sergi Sergi Lucia, Orlacchio Aldo, Naldini Luigi, Biffi Alessandra
Abstract excerpt
The balance between survival and death in many cell types is regulated by small changes in the intracellular content of bioactive sphingolipids. Enzymes that either produce or degrade these sphingolipids control this equilibrium. The findings here described indicate that the lysosomal galactocere...
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