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Article

Induction of G<sub>2</sub>/M Phase Arrest and Apoptosis by Oridonin in Human Laryngeal Carcinoma Cells

24 May 2010

Abstract excerpt

Oridonin (1), an active component isolated from the plant Rabdosia rubescens, has been reported to exhibit antitumor effects. In this study, the mechanism involved in 1-induced growth inhibition, including apoptosis and G(2)/M phase arrest, in human laryngeal carcinoma HEp-2 cells deficient in functional p53, was investigated for the first time. Compound 1 triggered the mitochondrial apoptotic pathway, as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20496901
DOI: 10.1021/np9008199

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