Sensitive detection and quantification of minimal residual disease in chronic myeloid leukaemia using nested quantitative PCR for <i>BCR‐ABL</i> DNA

Abstract excerpt

Increasing numbers of patients with chronic myeloid leukaemia (CML) treated with tyrosine kinase inhibitors achieve undetectable levels of BCR-ABL mRNA using sensitive quantitative real-time reverse transcriptase PCR (RT-qPCR) methods and a method to measure minimal residual disease (MRD) in patients with low levels could be of value. Following isolation and sequencing of the patient-specific BCR-ABL breakpoint,...

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