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A Spread-Deficient Cytomegalovirus for Assessment of First-Target Cells in Vaccination

13 May 2010

Abstract excerpt

Human cytomegalovirus (HCMV) is a human pathogen that causes severe disease primarily in the immunocompromised or immunologically immature individual. To date, no vaccine is available. We describe use of a spread-deficient murine CMV (MCMV) as a novel approach for betaherpesvirus vaccination. To generate a spread-deficient MCMV, the conserved, essential gene M94 was deleted. Immunization with MCMV-DeltaM94 is...

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PMID: 20463067
DOI: 10.1128/jvi.02696-09

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