Article
Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2010
Carthon Bradley C, Wolchok Jedd D, Yuan Jianda, Kamat Ashish, Ng Tang Derek S, Sun Jingjing, Ku Geoffrey, Troncoso Patricia, Logothetis Christopher J, Allison James P, Sharma Padmanee
Abstract excerpt
PURPOSE: Cytotoxic T lymphocyte associated antigen (CTLA-4) blockade is being explored in numerous clinical trials as an immune-based therapy for different malignancies. Our group conducted the first preoperative clinical trial with the anti-CTLA-4 antibody ipilimumab in 12 patients with localize...
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