Article
Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas.
BMC cancer - 6 May 2010
Sato Hiroaki, Uzawa Narikazu, Takahashi Ken-Ichiro, Myo Kunihiro, Ohyama Yoshio, Amagasa Teruo
Abstract excerpt
BACKGROUND: Although chromosomal instability (CIN) has been detected in many kinds of human malignancies by means of various methods, there is no practical assessment for small clinical specimens. In this study, we evaluated CIN in fine-needle aspiration (FNA) biopsied oral squamous cell carcinomas (SCCs) using fluorescence in situ hybridization (FISH) analysis, and investigated its prognostic significance....
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