Article
Genome-wide DNA methylation analysis in cohesin mutant human cell lines.
Nucleic acids research - 1 Sept 2010
Liu Jinglan, Zhang Zhe, Bando Masashige, Itoh Takehiko, Deardorff Matthew A, Li Jennifer R, Clark Dinah, Kaur Maninder, Tatsuro Kondo, Kline Antonie D, Chang Celia, Vega Hugo, Jackson Laird G, Spinner Nancy B, Shirahige Katsuhiko, Krantz Ian D
Abstract excerpt
The cohesin complex has recently been shown to be a key regulator of eukaryotic gene expression, although the mechanisms by which it exerts its effects are poorly understood. We have undertaken a genome-wide analysis of DNA methylation in cohesin-deficient cell lines from probands with Cornelia de Lange syndrome (CdLS). Heterozygous mutations in NIPBL, SMC1A and SMC3 genes account for ∼65% of individuals with...
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