Article
Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2010
Timpson Nicholas J, Brennan Paul, Gaborieau Valérie, Moore Lee, Zaridze David, Matveev Vsevolod, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Mates Dana, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Chow Wong-Ho, Rothman Nathaniel, Boffetta Paolo, Harbord Roger M, Smith George Davey
Abstract excerpt
BACKGROUND: Increased risk of renal cell carcinoma (RCC) with milk consumption has been reported from observational studies. Whether this represents a causal association or is a result of confounding or bias is unclear. We assessed the potential for using genetic variation in lactase persistence as a tool for the study of this relationship. METHODS: Using a large, hospital-based case-control study, we used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.