Article
Ethnic differences in alpha-1 antitrypsin deficiency in the United States of America.
Therapeutic advances in respiratory disease - 1 Apr 2010
de Serres Frederick J, Blanco Ignacio, Fernández-Bustillo Enrique
Abstract excerpt
BACKGROUND: Our earlier publications have demonstrated that alpha-1 antitrypsin (AAT) deficiency is not a rare disorder in the United States with at least 33,728 PI*ZZ homozygote individuals at risk. METHOD: Using data on the prevalences of the two most common deficiency alleles PI*S and PI*Z in the five major individual ethnic subgroups in the United States, the numbers of heterozygotes for PI*MS and PI*MZ, and...
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