Article
Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults.
Science (New York, N.Y.) - 23 Apr 2010
MacLennan Calman A, Gilchrist James J, Gordon Melita A, Cunningham Adam F, Cobbold Mark, Goodall Margaret, Kingsley Robert A, van Oosterhout Joep J G, Msefula Chisomo L, Mandala Wilson L, Leyton Denisse L, Marshall Jennifer L, Gondwe Esther N, Bobat Saeeda, López-Macías Constantino, Doffinger Rainer, Henderson Ian R, Zijlstra Eduard E, Dougan Gordon, Drayson Mark T, MacLennan Ian C M, Molyneux Malcolm E
Abstract excerpt
Nontyphoidal Salmonellae are a major cause of life-threatening bacteremia among HIV-infected individuals. Although cell-mediated immunity controls intracellular infection, antibodies protect against Salmonella bacteremia. We report that high-titer antibodies specific for Salmonella lipopolysaccharide (LPS) are associated with a lack of Salmonella-killing in HIV-infected African adults. Killing was restored by...
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