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Genetic Requirements for the Survival of Tubercle Bacilli in Primates

15 Apr 2010

Abstract excerpt

BACKGROUND: Tuberculosis (TB) leads to the death of 1.7 million people annually. The failure of the bacille Calmette-Guérin vaccine, synergy between AIDS and TB, and the emergence of drug resistance have worsened this situation. It is imperative to delineate the mechanisms employed by Mycobacterium tuberculosis to successfully infect and persist in mammalian lungs. METHODS: Nonhuman primates (NHPs) are arguably...

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Share to Immune responses and vaccinations
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PMID: 20394526
DOI: 10.1086/652497

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